Abstract:With the advent of the digital-intelligent era, the human-machine relationship is undergoing structural reorganization, giving rise to a new paradigm of human-space relationship. This transformation is reshaping both technological and social spatial frameworks, and is particularly prominent in the development and evolution of industrial space. From a techno-industrial perspective, this study systematically reviews the evolutionary trajectory of human-machine relationships. It argues that when machines acquire spatial agency, their geographical distribution will exhibit scenario-specific patterns, thereby necessitating adjustments to urban industrial spatial order. Contemporary research frontiers primarily focus on the spatial implications of machine substitution regarding employment displacement and regional pattern evolution, the transformation of industry-city relationships, and the intelligence of industrial space. However, a critical gap remains in the systematic thinking about emerging spatial paradigms. In response to technological trends and practical needs, this research proposes establishing a collaborative spatial analysis framework integrating the dimensions of "human—machine—land—industry," and identifies three priority research directions: Investigating human-mach