Abstract Under the background of building a new development pattern of "double cycle", it is of great significance to study the organizational characteristics of industrial space in the metropolitan area and put forward corresponding optimization strategies, so as to promote the in-depth integration of industrial chain and supply chain in the metropolitan area. Based on the data of micro enterprises, we adopt the research methods of "place space" and "flow space" to analyze the organizational characteristics and functional synergy of industrial space in Wuhan metropolitan area from the perspective of industrial clusters, and diagnose the existing problems. The results show that the industrial space of Wuhan metropolitan area presents a "point-axis" pattern in terms of "place space", and is characterized by "big dispersion and small concentration" of manufacturing industry and centralization of productive service industry. The results show that: in "place space", the industrial space of Wuhan metropolitan area shows a "point-axis" pattern, and is characterized by "large dispersion and small concentration" of manufacturing industry and concentration of productive service industry; in "flow space", the network of Wuhan metropolitan area is significantly polarized, and the level of functional synergy is yet to be improved. We discuss the perceptual diagnosis and simulation methods based on "place space" and "flow space" from the aspects of shape-flow combination, shape-flow simulation and shape-flow determination, and summarize the " It also summarizes the layout optimization rules of "core+axis" structure, division of labor between inner and outer circles, and cooperation and co-construction of critical zones for the industrial space of strong-core growth metropolitan area.