Abstract Innovation-driven development has become an important national strategy, which in turn has triggered fierce competition among regions around innovation factors. Based on the discussion of the general law and paradox of free flow of innovation factors, it is believed that the improvement of regional innovation level requires not only the spontaneous regulation of market mechanism, but also the appropriate cross-domain reorganization of innovation factors. On the basis of analyzing the realistic dilemma of the current spatial governance means for various types of innovation factors, the "reverse enclave" path of cross-domain reorganization of innovation factors is proposed in the case of Quzhou Hi-Tech Park, and it is argued that, through the innovation of the cooperation mechanism, the model can promote the reorganization and configuration optimization of innovation factors on a regional scale, and realize the double innovation agglomeration effect and the diffusion effect. Improvement. Aiming at the bottlenecks in practice, the planning and governance strategy of "reverse enclave" is proposed, namely, building a multi-center and networked "reverse enclave" collaborative innovation pattern, exploring the "reverse enclave" spatial supply paradigm to adapt to the cross-domain flow of innovations, establishing a robust "reverse enclave" spatial supply paradigm, and establishing the "reverse enclave" spatial supply model. It proposes planning and governance strategies for "reverse enclaves", namely, building a multi-centered and networked "reverse enclave" collaborative innovation pattern, exploring a "reverse enclave" spatial supply paradigm that accommodates cross-domain flows of innovation, and establishing a sound enclave innovation governance system based on new regionalism.