Abstract: The development transformation of the Guangdong-Hong Kong-Macao Greater Bay Area profoundly reflects the interactive logic between the evolution of regional models and the reconfiguration of national space. Based on the theoretical framework of national space, this paper discusses the structural process of the regional model and argues that: in the early stage of the "Pearl River Model", under its geographic location, social and institutional advantages, the "introduction-digestion" of industrial technology was embedded in the global industrial system, and decentralized competition effectively stimulated the vitality of the region. With the intensification of the negative effects of the regional economy, the transition to the "Bay Area Model" of regional synergy was initiated after 2008, and the national spatial form shifted from decentralized experimentation to strategic integration, with the Guangdong-Hong Kong-Macao Greater Bay Area realizing "re-domainization" in the reorganization of the scales. The Guangdong-Hong Kong-Macao Greater Bay Area has achieved "re-domainization" in the scale reorganization, and is moving towards a polycentric metropolitan area structure; in the future, regional planning and governance will require the construction of innovative spatial policy tools to coordinate institutional innovations and territorial reorganization mechanisms, to achieve the effective allocation of regional factors of production and promote the coordinated development and optimization of the spatial layout of the region.