Abstract: Under the strategic guidance of ecological civilization and building a maritime power, "blue economy" has become a new engine driving Chinas economic growth. The optimization of industrial spatial layout of coastal zones is crucial to handling the relationship between high-quality development of Marine cities and high-level protection. Multi-scale overall perspective and key grasp is the key to improve the comprehensive benefits of coastal zone industrial spatial planning. Starting from the land and sea coordination goal of territorial space planning and the practical problems of provincial coastal zone industrial development, the multi-scale cross-border coordination theoretical framework of "external environment- -internal pattern- -resource elements" is constructed, and the cross-border coordination path of "region-provincial-bay area" is put forward. Based on the theoretical method, it is suggested that Fujian province should cultivate the "land-sea double-fan" global ocean center city cluster between Fujian and Taiwan at the regional level, build a spatial pattern of large density, large density and low influence at the provincial level, and build diversified bay units with land-sea coordination and industry-city integration at the bay level. The research can provide theoretical and practical reference for the high-quality development of provincial coastal zone industry and the comprehensive management of land and sea.